In his final year at Penn State, Enis ran for 1,363 yards and 20 touchdowns. That season was his second consecutive 1,000-yard rushing season, so Enis left for the NFL and was taken fifth overall in the 1998 draft by the Chicago Bears.
Somehow, his NFL career lasted exactly as long as his tenure at Penn State. As a rookie, Enis ran for 497 yards in nine games while averaging 3.7 yards per carry. His first year was ended by a torn ligament in his knee.
Enis returned in 1999 to run for 916 yards in 15 games with three touchdowns. It was his most productive season. The next year he was supplanted at running back by James Allen and with his 6-foot 240-pound frame he was forced to play fullback in his final NFL season.