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Ranking the biggest games on the 2022 Penn State Football schedule

By Nick Kreiser

STATE COLLEGE, PA - NOVEMBER 13: Keyvone Lee #24 of the Penn State Nittany Lions carries the ball against Rod Moore #19 of the Michigan Wolverines during the second half at Beaver Stadium on November 13, 2021 in State College, Pennsylvania. (Photo by Scott Taetsch/Getty Images)
STATE COLLEGE, PA - NOVEMBER 13: Keyvone Lee #24 of the Penn State Nittany Lions carries the ball against Rod Moore #19 of the Michigan Wolverines during the second half at Beaver Stadium on November 13, 2021 in State College, Pennsylvania. (Photo by Scott Taetsch/Getty Images) /
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COLUMBUS, OHIO – OCTOBER 30: TreVeyon Henderson #32 of the Ohio State Buckeyes runs the ball past Ji’Ayir Brown #16 of the Penn State Nittany Lions during the second half of their game at Ohio Stadium on October 30, 2021 in Columbus, Ohio. (Photo by Emilee Chinn/Getty Images)
COLUMBUS, OHIO – OCTOBER 30: TreVeyon Henderson #32 of the Ohio State Buckeyes runs the ball past Ji’Ayir Brown #16 of the Penn State Nittany Lions during the second half of their game at Ohio Stadium on October 30, 2021 in Columbus, Ohio. (Photo by Emilee Chinn/Getty Images) /

2. Penn State Football vs Ohio State (10/29)

I told you this list was going to go against the grain.

An upset win over Ohio State would certainly be the biggest win of the season, but it would also be the most anticipated loss.

Do I expect the Nittany Lions to compete with the Buckeyes? Absolutely, they always do, especially at home.

Do I think Penn State Football has a chance to pull off an upset? Again, yes. As the saying goes, “on any given Saturday, anything can happen in college football.”

However, Ohio State is one of the most talented teams – and arguably the best offense – in the entire country, so they will be a tough out.

If the Nittany Lions are undefeated, or even have just one loss by October 29th when the Buckeyes come to town, then this will easily become the biggest game of the season, but four of the other five games on this list occur before that point, including the next one on the list, which just so happens to take place a week before this Ohio State game.

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