2. Penn State Football vs Ohio State (10/29)
I told you this list was going to go against the grain.
An upset win over Ohio State would certainly be the biggest win of the season, but it would also be the most anticipated loss.
Do I expect the Nittany Lions to compete with the Buckeyes? Absolutely, they always do, especially at home.
Do I think Penn State Football has a chance to pull off an upset? Again, yes. As the saying goes, “on any given Saturday, anything can happen in college football.”
However, Ohio State is one of the most talented teams – and arguably the best offense – in the entire country, so they will be a tough out.
If the Nittany Lions are undefeated, or even have just one loss by October 29th when the Buckeyes come to town, then this will easily become the biggest game of the season, but four of the other five games on this list occur before that point, including the next one on the list, which just so happens to take place a week before this Ohio State game.